Partner 6

A genetic locus required for iron acquisition in Mycobacterium tuberculosis.
R. Krithika, U. Marathe, P. Saxena, M.Z. Ansari, D. Mohanty, R.S. Gokhale PNAS USA 2006,103, 2069-2074.

Promiscuous fatty acyl-CoA ligases produce acyl-CoA and acyl-SNAC precursors for polyketide biosynthesis.
P. Arora, A. Vats, P. Saxena, D. Mohanty, R.S. Gokhale J. Am. Chem. Soc. 2005, 127, 9388- 9389.

Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid.
O.A. Trivedi, P. Arora, A. Vats, M.Z. Ansari, R. Tickoo, V. Sridharan, D. Mohanty, R.S. Gokhale Mol. Cell. 2005, 17, 631-643.

A novel substrate binding tunnel in mycobacterial type III polyketide synthase reveals structural basis for generating diverse metabolites.
R. Sankarnarayanan, P. Saxena, U.B. Marathe, R.S. Gokhale, V.M. Shanmugam, R. Rukmini Nat. Struct. Mol. Biol. 2004, 11, 894-900.

Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria.
O.A. Trivedi, P. Arora, V. Sridharan, R. Tickoo, D. Mohanty, R.S. Gokhale Nature 2004, 428, 441-445.

A New Family of Type III Polyketide Synthases in Mycobacterium tuberculosis.
P. Saxena, G. Yadav, D. Mohanty, R.S. Gokhale J. Biol. Chem. 2003, 278, 44780-44790

Title: New Approaches to Target Tuberculosis

Acronym: NATT

Contract number: 222965

EC contribution: 2.994.478 €

Duration: 36 months

Starting date: 01/10/2008

Collaborative project