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Publications

Partner 3

Five- and six-membered conformationally Locked 2',4'-Carbocyclic ribo-Thymidine: Synthesis, Structure and biochemical studies.
P. Srivastava, J. Barman, W. Pathmasiri, O. Plashkevych, M. Wenska, J. Chattopadhyaya J. Am. Chem. Soc. 2007, 129, 8362-8379.

Chemical and Structural Implications of 1',2'- versus 2',4'- Conformational Constraints in the Sugar Moiety of Modified Thymine Nucleosides
O. Plashkevych, S. Chatterjee, D. Honcharenko, J. Chattopadhyaya J. Org. Chem. 2007, 72, 4716-4726.

Comparison of the RNase H Cleavage Kinetics and Blood Serum Stability of the North-Conformationally Constrained and 2'-Alkoxy Modified Oligonucleotides.
D. Honcharenko, J. Barman, O. P. Varghese, J. Chattopadhyaya Biochemistry 2007, 46, 5635- 5646.

Conformationally Constrained 2'-N,4'-C-Ethylene-Bridged Thymidine (Aza-ENA-T): Synthesis, Structure, Physical, and Biochemical Studies of Aza-ENA-T-Modified Oligonucleotides.
O. P., Varghese, J. Barman, W. Pathmasiri, O. Plashkevych, D. Honcharenko, J. Chattopadhyaya J. Am. Chem. Soc. 2006, 128, 15173-15187.

The chemical nature of 2'-substituent in the pentose-sugar dictates the pseudoaromatic character of the nucleobase (pKa) in DNA/RNA.
S. Chatterjee, W. Pathmasiri, O. Plashkevych, D. Honcharenko, O. P. Varghese, M. Maiti, J. Chattopadhyaya Org. Biomol. Chem. 2006, 4, 1675-1686.

Title: New Approaches to Target Tuberculosis


Acronym: NATT


Contract number: 222965


EC contribution: 2.994.478 €


Duration: 36 months


Starting date: 01/10/2008


Instrument:
Collaborative project